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• A. Heinz, A. Beck, J. Wrase, J. Mohr, K. Obermayer, J. Gallinat, and I. Puls. Neurotransmitter Systems in Alcohol Dependence. . Pharmacopsychiatry, 42(S 01):S95-S101, 2009.
  

  An interplay of different neurotransmitter systems has been implicated in the development and maintenance of alcohol dependence. Here we focus on neuroadaptations in reward-related neurotransmitter systems and their impact on central processing of alcohol-associated and reward-indicating stimuli. We discuss genotype effects on cue-induced neuronal activation and present new computational methods based on machine learning to deal with complex genotype-phenotype interactions, e.g. between brain atrophy and genes associated with glutamatergic and dopaminergic neurotransmission.