Browse all publications by topic
Browse all publications by year
- J. M. Young, W. J.
Waleszczyk, C. Wang, M. B. Calford, B. Dreher, and K. Obermayer. Cortical
reorganization consistent with spike timing- but not correlation-dependent
plasticity.
.
Nature Neuroscience, 10:887-889, 2007.
The receptive fields of neurons in primary visual cortex that are
inactivated by retinal damage are known to 'shift' to nondamaged retinal
locations, seemingly due to the plasticity of intracortical connections. We
have observed in cats that these shifts occur in a pattern that is highly
convergent, even among receptive fields that are separated by large distances
before inactivation. Here we show, using a computational model of primary
visual cortex, that the observed convergent shifts are inconsistent with the
common assumption that the underlying intracortical connection plasticity is
dependent on the temporal correlation of pre- and postsynaptic action
potentials. The shifts are, however, consistent with the hypothesis that this
plasticity is dependent on the temporal order of pre- and postsynaptic action
potentials. This convergent reorganization seems to require increased
neuronal gain, revealing a mechanism that networks may use to selectively
facilitate the didactic transfer of neuronal response
properties.
|
